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The following article provides more detailed information on the use, side effects, and drawbacks of this drug. Shock 13. It’s a drug that blocks the action of serotonin, a naturally occurring substance that can lead to nausea and vomiting. Ondansetron orally disintegrating tablet may cause drowsiness. "Product Information. Things to remember when you fill your prescription. Hundreds of women have turned to the legal system to get justice and restitution for unexpected side effects that have changed lives forever. The National Institutes of Health lists the following as common side effects. You may report them to the FDA. Side effects. It is not covered by most Medicare and insurance plans, but manufacturer and pharmacy coupons can help offset the cost. Ondansetron (Zofran) is a moderately priced drug used to treat nausea and vomiting caused by chemotherapy. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Doctors also prescribe it to pregnant women who have extreme or debilitating morning sickness. 2. Zofran is a drug with problematic side effects. Ondansetron is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation therapy. Temporary Blindness 16. Zofran (ondansetron) is an antiemetic and selective 5-HT3 receptor antagonist prescribed for the treatment of nausea and vomiting due to cancer chemotherapy and also used to prevent and treat nausea and vomiting after surgery. Prolonged QT Interval On EKG 12. [Ref], Common (1% to 10%): Anxiety/agitation, disturbance in behavior/conduct, sleep disturbance[Ref], Common (1% to 10%): Gynecological disorder, urinary retention, urinary tract infection/dysuria[Ref], Very rare (less than 0.01%): Toxic skin eruption, toxic epidermal necrolysis[Ref], Common (1% to 10%): Asymptomatic increases in AST/ALT, Postmarketing reports: Liver failure and death[Ref]. Zofran Complaints Reported in Canada. [Ref], Common (1% to 10%): Injection site reactions[Ref], Rare (0.01% to 0.1%): Immediate hypersensitivity reactions (sometimes severe), anaphylaxis/anaphylactoid reactions, Frequency not reported: Poor oral intake[Ref], 1. Zofran side effects Get emergency medical help if you have signs of an allergic reaction to Zofran: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat. Life Threatening Allergic Reaction 11. Common Zofran side effects include: In the ondansetron prescribing label information (Zofran®, Zofran ODT® package insert), the most commonly reported ondansetron (Zofran®, Zofran ODT®) side effects are shown here. If experienced severely or for a … All medications have side effects, including Zofran. It is also used to prevent or treat nausea and vomiting after surgery. Ondansetron is a common medication that can be used to treat vomiting in dogs and cats. The more common side effects of ondansetron can include: [Ref], Common (1% to 10%): Sensation of warmth/flushing, bradycardia, hypotension, arrhythmias, Uncommon (0.1% to 1%): Chest pain with/without ST segment depression, Rare (0.01% to 0.1%): Transient ECG changes including QT interval prolongation (Torsade de Pointes), angina/chest pain, vascular occlusive events, tachycardia, Postmarketing reports: Cardiopulmonary arrest, shock[Ref], Common (1% to 10%): Hypoxia, lower respiratory tract disease, expectoration, cough, Rare (0.01% to 0.1%): Bronchospasm/asthma, Postmarketing reports: Shortness of breath, laryngeal edema, stridor, laryngospasm[Ref], Laryngospasm occurred during allergic reactions in patients given the IV formulation. Check with your doctor immediately if any of the following side effects occur while taking ondansetron: Some side effects of ondansetron may occur that usually do not need medical attention. Dizziness occurred during rapid IV administration. Some of the dosage forms listed on this page may not apply to the brand name Zofran. In clinical trials of patients taking Zofran to prevent nausea and vomiting associated with chemotherapy, nearly a quarter of patients taking 8 mg of the drug twice daily experienced a headache. The safety of Zofran during pregnancy is an issue in Canada as well. Transient visual disturbances, blurred vision, and transient blindness occurred predominantly during rapid IV administration. Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor immediately if any of the following side effects occur while taking onda… Decreased Oxygen In The Tissues Or Blood 7. Headache, lightheadedness, dizziness, drowsiness, tiredness, or constipation may occur. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Acute Liver Failure 5. side effects The following have been reported as adverse events in clinical trials of patients treated with ondansetron, the active ingredient of ondansetron hydrochloride tablets. Side Effects. In fact, along with the risks of birth defects in their infants, other side effects that directly affect the mother include: Call your doctor at once if you have: This drug is more popular than comparable drugs. Potential pregnancy side effects of Zofran have been linked to an increased risk of unborn babies developing serious … Selected from data included with permission and copyrighted by First Databank, Inc. Along with its needed effects, ondansetron (the active ingredient contained in Zofran) may cause some unwanted effects. Stevens-Johnson Syndrome 15. Zofran is available in generic form. WebMD does not provide medical advice, diagnosis or treatment. Zuplenz (ondansetron)." A causal relationship to therapy with ondansetron hydrochloride has been unclear in many cases. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Studies have linked Zofran to severe side effects, including birth defects, heart defects, cleft palate, and more. [Ref], Wound problems occurred at the surgical site in patients given this drug for the treatment of postoperative nausea and vomiting. Abnormal Heart Electrical Signals 2. It can be given by mouth or by injection into a muscle or into a vein. Side Effects. Extrapyramidal Reaction 8. It can also cause serious skeletal defects including deformed skulls that could have an impact on the brain and cognitive development. "Product Information. Some side effects may not be reported. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Bronchospasm 6. Unlike some other nausea medicines, the side effects for Zofran (ondansetron… We comply with the HONcode standard for trustworthy health information -. At the extreme end, the use of the drug caused fetal death including miscarriage and stillbirth. Applies to ondansetron: film, solution, tablet, tablet disintegrating. If experienced, these tend to have a Severe expression 1. Zofran is linked to possible side effects, some of which are serious, including serotonin syndrome and QT interval prolongation. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Medically reviewed by Drugs.com. It is unknown if Zofran enters breast milk. If these effects persist or worsen, notify your doctor promptly.Remember that your doctor has prescribed this medication because he or she has judged that the … Ondansetron is in a class of medications called serotonin 5-HT3 receptor antagonists. It is also used to prevent nausea and vomiting that may occur after surgery. Most side effects of Zofran are mild or moderate, but some may be severe or life-threatening. If you struggle with nausea … If these effects persist or worsen, notify your doctor promptly. This drug is more popular than comparable drugs. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Liver failure and death have been reported in patients with cancer receiving potentially hepatotoxic/cytotoxic chemotherapy and antibiotics; however, the etiology of liver failure is unknown. Giant Hives 10. O 0. Cerner Multum, Inc. "Australian Product Information." More common side effects. Zofran (ondansetron) comes in many different forms that you don't have to swallow, such as a film that goes on the tongue or a dissolving pill. difficulty with passing urine (dribbling), puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, increased blinking or spasms of the eyelid, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, uncontrolled twisting movements of the neck, trunk, arms, or legs, difficulty having a bowel movement (stool), uncontrolled movements, especially of the face, neck, and back, redness of the face, neck, arms, and occasionally, upper chest. Last updated on Nov 11, 2020. Zofran Side Effects Include Injuries to Mothers and Babies. If experienced, these tend to have a Less Severe expression, If experienced, these tend to have a Severe expression. Zofran Side Effects When given to a pregnant woman, Zofran can cause a wide range of birth defects. Cerner Multum, Inc. "UK Summary of Product Characteristics." Although not all of these side effects may occur, if they do occur they may need medical attention. All rights reserved. Multimedia: Slideshows, Images & Quizzes Oculogyric crisis occurred alone and in combination with other dystonic reactions. The effects of Zofran were never investigated in clinical trials that included pregnant women, and thus there are no clinical trials targeting pregnant women that would provide us with a way of knowing what side effects it may cause in them or harm it may do to developing babies. 3. Zofran (ondansetron) is fast-acting and starts working within 30 minutes. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter, A Condition Where The Body Is Unable To Maintain Adequate Blood Flow Called Shock, A Significant Type Of Allergic Reaction Called Anaphylaxis, A Skin Disorder With Blistering And Peeling Skin Called Stevens-Johnson Syndrome, A Skin Disorder With Blistering And Peeling Skin Called Toxic Epidermal Necrolysis, A Type Of Allergic Reaction Called Angioedema, Extrapyramidal Disease, A Type Of Movement Disorder, Painful And Involuntary Movement Of The Eyes Called Oculogyric Crisis, Torsades De Pointes, A Type Of Abnormal Heart Rhythm, An Inability To Completely Empty The Bladder. Fast Heartbeat 9. Common side effects associated with Zofran include headache, drowsiness, constipation and the chills. How long before a meal should you take ondansetron? Many times, it is used for people receiving cancer treatments, such as radiation therapy or chemotherapy. Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. It is available in brand and generic form. Headache occurred more often in the oral dissolving tablet formulation when taken with water. Slow Heartbeat 14. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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